During the last decades, several windstorm series hit Europe leading to large aggregated losses.Such storm series are examples of serial clustering of extreme cyclones, presenting a considerable risk for the insurance industry.Clustering of events and return periods of storm series for Germany are quantified based on potential losses using empirica
Abstract ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins.We previously found that ATG9A does not co-assemble into synaptophysin-positive vesicles, but rather, localizes to a distinct pool of vesicles within synapsin condensates in both fibroblasts and nerve terminals.The endocytic origin of these vesicles fur
Amyotrophic lateral sclerosis (ALS) is a fatal condition characterized by the selective loss of motor neurons in the motor cortex, brainstem, and spinal cord.Muscle involvement, muscle atrophy, and subsequent paralysis are among the main features of this disease, which is defined as a neuromuscular disorder.ALS is a persistently progressive disease
Abstract The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression.Within the TME, angiogenesis is predominantly orchestrated by endothelial cells (ECs), which foster the proliferation and metastas